Therefore, we investigated the impact of PDE 4 inhibitors and anticholinergics on bronchoconstriction-inducedĪ comparison of the inhibitory activity of selective PDE 4 inhibitors on eosinophil recruitment in guinea pig skinĭirectory of Open Access Journals (Sweden)įull Text Available The elevation of intracellular cyclic AMP by phosphodiesterase ( PDE 4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. Mechanical forces that arise during bronchoconstriction may contribute to airway remodeling. Schmidt, Martina Facchinetti, Fabrizio Civelli, Maurizio Villetti, Gino Gosens, ReinoudĬombination therapy of PDE 4 inhibitors and anticholinergics induces bronchoprotection in COPD.
Kistemaker, Loes E M Oenema, Tjitske A Baarsma, Hoeke A Bos, I.
The PDE 4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices
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